Pathologic physiology and chemotherapy of Plasmodium berghei
Identifieur interne : 003C92 ( Main/Exploration ); précédent : 003C91; suivant : 003C93Pathologic physiology and chemotherapy of Plasmodium berghei
Auteurs : Frank Palecek [États-Unis] ; Mila Palecekova [États-Unis] ; Domingo M. Aviado [États-Unis]Source :
- Experimental Parasitology [ 0014-4894 ] ; 1967.
English descriptors
- Teeft :
- Acidosis, Aviado, Berghei, Blood hemoglobin, Blood oxygen, Blood sample, Blood samples, Carbon dioxide, Carbon dioxide concentration, Chloroquine, Conditioning system, Control mice, Dioxide, Dissociation, Dissociation curve, Dissociation curves, Erythrocyte, Ferricyanide solution, Hemoglobin, Hemoglobin content, Human blood, Human form, Inoculated, Iron metabolism, Lactic acid, Laver, Malaria, Malarial, Malarial blood, Malarial mice, Malarial parasite, Mice inoculated, Mouse, Mouse blood, Next series, Noninfected, Noninfected mice, Nontreated controls, Normal blood, Normal controls, Normal erythrocytes, Normal mice, Other values, Oxygen capacity, Oxygen content, Oxygen saturation, Oxygen tension, Oxygen uptake, Oxyhemoglobin, Oxyhemoglobin dissociation curve, Palecek, Palecekova, Parasite, Parasite count, Parasitemia, Parasitized erythrocytes, Pathologic physiology, Pathological processes, Plasmodium, Plasmodium berghei, Progressive parasitemia, Progressive reduction, Resistant, Resistant malaria, Resistant strain, Resistant strains, Rigdon, Rodent malaria, Rostorfer, Same features, Saturation, Sensitive strain, Sherwood jones, Total hemoglobin, Tropical medicine.
Abstract
Abstract: Mice inoculated with Plasmodium berghei die of progressive parasitemia and anemia in about 7 days postinoculation. The blood collected from mice sacrificed on days 4, 5, 6, and 7 after inoculation revealed the following features which contrast with blood from normal noninfected mice: (1) reduction in hemoglobin content; (2) reduction in oxygen content, when blood was equilibrated with gas mixtures of 5.25, 9.84, 19.9, and 93.85% oxygen and 5.12, 5.46, 4.95, and 6.15% carbon dioxide, respectively; (3) reduction in blood pH when blood was equilibrated with the above mentioned gas mixtures; and (4) the dissociation curve for oxyhemoglobin was shifted to the right. The blood collected from the mice infected with chloroquine-resistant strain of P. berghei showed essentially the same features as the blood from the mice inoculated with the sensitive strain with the following minor difference: the anemia was more severe but the parasitemia was less intense in the mice with chloroquine-resistant strain. The dissociation curve for the oxyhemoglobin obtained from mice infected with resistant strain was between the curve from noninfected mice and the curve from mice infected with sensitive strain.
Url:
DOI: 10.1016/0014-4894(67)90063-X
Affiliations:
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Aviado</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Experimental Parasitology</title><title level="j" type="abbrev">YEXPR</title><idno type="ISSN">0014-4894</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1967">1967</date><biblScope unit="volume">21</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="16">16</biblScope><biblScope unit="page" to="30">30</biblScope></imprint><idno type="ISSN">0014-4894</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0014-4894</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acidosis</term><term>Aviado</term><term>Berghei</term><term>Blood hemoglobin</term><term>Blood oxygen</term><term>Blood sample</term><term>Blood samples</term><term>Carbon dioxide</term><term>Carbon dioxide concentration</term><term>Chloroquine</term><term>Conditioning system</term><term>Control mice</term><term>Dioxide</term><term>Dissociation</term><term>Dissociation curve</term><term>Dissociation curves</term><term>Erythrocyte</term><term>Ferricyanide solution</term><term>Hemoglobin</term><term>Hemoglobin content</term><term>Human blood</term><term>Human form</term><term>Inoculated</term><term>Iron metabolism</term><term>Lactic acid</term><term>Laver</term><term>Malaria</term><term>Malarial</term><term>Malarial blood</term><term>Malarial mice</term><term>Malarial parasite</term><term>Mice inoculated</term><term>Mouse</term><term>Mouse blood</term><term>Next series</term><term>Noninfected</term><term>Noninfected mice</term><term>Nontreated controls</term><term>Normal blood</term><term>Normal controls</term><term>Normal erythrocytes</term><term>Normal mice</term><term>Other values</term><term>Oxygen capacity</term><term>Oxygen content</term><term>Oxygen saturation</term><term>Oxygen tension</term><term>Oxygen uptake</term><term>Oxyhemoglobin</term><term>Oxyhemoglobin dissociation curve</term><term>Palecek</term><term>Palecekova</term><term>Parasite</term><term>Parasite count</term><term>Parasitemia</term><term>Parasitized erythrocytes</term><term>Pathologic physiology</term><term>Pathological processes</term><term>Plasmodium</term><term>Plasmodium berghei</term><term>Progressive parasitemia</term><term>Progressive reduction</term><term>Resistant</term><term>Resistant malaria</term><term>Resistant strain</term><term>Resistant strains</term><term>Rigdon</term><term>Rodent malaria</term><term>Rostorfer</term><term>Same features</term><term>Saturation</term><term>Sensitive strain</term><term>Sherwood jones</term><term>Total hemoglobin</term><term>Tropical medicine</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Mice inoculated with Plasmodium berghei die of progressive parasitemia and anemia in about 7 days postinoculation. The blood collected from mice sacrificed on days 4, 5, 6, and 7 after inoculation revealed the following features which contrast with blood from normal noninfected mice: (1) reduction in hemoglobin content; (2) reduction in oxygen content, when blood was equilibrated with gas mixtures of 5.25, 9.84, 19.9, and 93.85% oxygen and 5.12, 5.46, 4.95, and 6.15% carbon dioxide, respectively; (3) reduction in blood pH when blood was equilibrated with the above mentioned gas mixtures; and (4) the dissociation curve for oxyhemoglobin was shifted to the right. The blood collected from the mice infected with chloroquine-resistant strain of P. berghei showed essentially the same features as the blood from the mice inoculated with the sensitive strain with the following minor difference: the anemia was more severe but the parasitemia was less intense in the mice with chloroquine-resistant strain. The dissociation curve for the oxyhemoglobin obtained from mice infected with resistant strain was between the curve from noninfected mice and the curve from mice infected with sensitive strain.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Palecek, Frank" sort="Palecek, Frank" uniqKey="Palecek F" first="Frank" last="Palecek">Frank Palecek</name></region><name sortKey="Aviado, Domingo M" sort="Aviado, Domingo M" uniqKey="Aviado D" first="Domingo M." last="Aviado">Domingo M. Aviado</name><name sortKey="Palecekova, Mila" sort="Palecekova, Mila" uniqKey="Palecekova M" first="Mila" last="Palecekova">Mila Palecekova</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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